Motor function was evaluated using the sciatic functional index (SFI) every week. The iES and tES groups received stimulation for 6 weeks starting immediately after the injury. Eighteen Sprague Dawley rats were classified into three groups: the iES group stimulated with fully implantable device, the tES group stimulated with transcutaneous electrical nerve stimulation (TENS), and the injury group (no stimulation). The present study compared the effectiveness of invasive and non-invasive stimulation using similar parameters. However, due to the use of different parameters in these studies, a fair comparison between the effectiveness of invasive and non-invasive stimulation methods is not possible. Several studies have investigated the use of invasive and non-invasive stimulation methods to enhance nerve regeneration, and varying degrees of effectiveness have been reported.
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